GPC2-CAR T cells tuned for low antigen density mediate potent

Pediatric cancers often mimic fetal tissues and express proteins normally silenced postnatally that could serve as immune targets. We developed T cell…

Preclinical development of a chimeric antigen receptor T cell therapy targeting FGFR4 in rhabdomyosarcoma - ScienceDirect

Mechanisms and strategies for safe chimeric antigen receptor T‐cell activity control - Stock - 2023 - International Journal of Cancer - Wiley Online Library

Strategies to enhance CAR-T persistence, Biomarker Research

Preclinical development of a chimeric antigen receptor T cell therapy targeting FGFR4 in rhabdomyosarcoma - ScienceDirect

Development of GPC2-directed chimeric antigen receptors using mRNA for pediatric brain tumors

JCI - An optimized bicistronic chimeric antigen receptor against GPC2 or CD276 overcomes heterogeneous expression in neuroblastoma

Antigen-dependent IL-12 signaling in CAR T cells promotes regional to systemic disease targeting

GPC2-CAR T cells tuned for low antigen density mediate potent activity against neuroblastoma without toxicity - ScienceDirect

Development of GPC2-directed chimeric antigen receptors using mRNA for pediatric brain tumors

JCM, Free Full-Text

CAR T cells targeting tumor-associated exons of glypican 2 regress neuroblastoma in mice. - Abstract - Europe PMC

Overcoming on-target, off-tumour toxicity of CAR T cell therapy for solid tumours. - Abstract - Europe PMC

Full article: B7-H3-targeted CAR-T cell therapy for solid tumors

D3-GPC2-PBD is potently cytotoxic to GPC2-expressing SCLCs (A)