Noncanonical Functions of the Polycomb Group Protein EZH2 in Breast Cancer - ScienceDirect
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Last updated 19 fevereiro 2025
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Enhancer of Zeste Homologue 2 (EZH2) is the catalytic subunit of the polycomb repressive complex 2 (PRC2) that is critical for determining cell identi…
![Noncanonical Functions of the Polycomb Group Protein EZH2 in Breast Cancer - ScienceDirect](https://www.jbc.org/cms/asset/bdc6c155-d90c-4436-aae4-a9f9cfdcb781/gr3.jpg)
Inhibition of Ezh2 redistributes bivalent domains within transcriptional regulators associated with WNT and Hedgehog pathways in osteoblasts - Journal of Biological Chemistry
![Noncanonical Functions of the Polycomb Group Protein EZH2 in Breast Cancer - ScienceDirect](https://media.springernature.com/lw685/springer-static/image/chp%3A10.1007%2F978-3-031-42365-9_3/MediaObjects/532112_1_En_3_Fig3_HTML.png)
Introduction to Cancer Epigenetics
![Noncanonical Functions of the Polycomb Group Protein EZH2 in Breast Cancer - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S1043661822001049-ga1.jpg)
Focus on the classical and non-classical functions of EZH2: Guide the development of inhibitors and degraders - ScienceDirect
![Noncanonical Functions of the Polycomb Group Protein EZH2 in Breast Cancer - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S2589004223011926-gr3.jpg)
An EZH2-NF-κB regulatory axis drives expression of pro-oncogenic gene signatures in triple negative breast cancer - ScienceDirect
![Noncanonical Functions of the Polycomb Group Protein EZH2 in Breast Cancer - ScienceDirect](https://www.mdpi.com/ijms/ijms-21-09501/article_deploy/html/images/ijms-21-09501-g002.png)
IJMS, Free Full-Text
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JARID2 and EZH2, the eminent epigenetic drivers in human cancer - ScienceDirect
![Noncanonical Functions of the Polycomb Group Protein EZH2 in Breast Cancer - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S0024320522007081-gr5.jpg)
Combined inhibition of EZH2 and CD73 molecules by folic acid-conjugated SPION-TMC nanocarriers loaded with siRNA molecules prevents TNBC progression and restores anti-tumor responses - ScienceDirect
![Noncanonical Functions of the Polycomb Group Protein EZH2 in Breast Cancer - ScienceDirect](https://www.futuremedicine.com/cms/10.2217/fon.10.157/asset/images/medium/figure3.gif)
Epigenetic factors in cancer development: Polycomb group proteins
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EZH2 expression is associated with inferior overall survival in mantle cell lymphoma - Modern Pathology
![Noncanonical Functions of the Polycomb Group Protein EZH2 in Breast Cancer - ScienceDirect](https://www.cell.com/cms/attachment/1d88724f-7208-4b51-8aed-8d539d6f7666/fx1_lrg.jpg)
CBX2 and EZH2 cooperatively promote the growth and metastasis of lung adenocarcinoma: Molecular Therapy - Nucleic Acids
![Noncanonical Functions of the Polycomb Group Protein EZH2 in Breast Cancer - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S2211124718317984-fx1.jpg)
Polycomb- and Methylation-Independent Roles of EZH2 as a Transcription Activator - ScienceDirect
![Noncanonical Functions of the Polycomb Group Protein EZH2 in Breast Cancer - ScienceDirect](https://media.springernature.com/lw685/springer-static/image/chp%3A10.1007%2F978-3-031-42365-9_3/MediaObjects/532112_1_En_3_Fig8_HTML.png)
Introduction to Cancer Epigenetics
![Noncanonical Functions of the Polycomb Group Protein EZH2 in Breast Cancer - ScienceDirect](https://www.modernpathology.org/cms/attachment/675e0f2e-615d-4afb-ad60-5191207c28ed/gr2_lrg.jpg)
EZH2 expression is associated with inferior overall survival in mantle cell lymphoma - Modern Pathology
![Noncanonical Functions of the Polycomb Group Protein EZH2 in Breast Cancer - ScienceDirect](https://onlinelibrary.wiley.com/cms/asset/37963fda-e58d-46c8-a436-717fe111b300/cas14840-toc-0001-m.jpg?trick=1701159398127)
The noncanonical role of EZH2 in cancer - Huang - 2021 - Cancer Science - Wiley Online Library
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Suppression of canonical TGF-β signaling enables GATA4 to interact with H3K27me3 demethylase JMJD3 to promote cardiomyogenesis - Journal of Molecular and Cellular Cardiology
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