Effect of perioperative magnesium sulfate and labetalol infusion on peripheral perfusion and postoperative pain in nasal surgery: a randomized controlled trial, Patient Safety in Surgery
Por um escritor misterioso
Last updated 29 maio 2024
Maintenance of adequate peripheral perfusion during controlled hypotension is necessary for patient safety and improved surgical outcomes during controlled hypotension in nasal surgery. The hypothesis of this study was to investigate the effect of perioperative magnesium sulfate and labetalol infusion on peripheral perfusion and postoperative pain in patients undergoing nasal surgery. A total of 50 patients were randomly assigned into two equal groups in this double-blind clinical study: the magnesium sulfate group; received 40 mg/kg loading dose of intravenous (IV) magnesium sulfate followed by 10–15 mg/kg/h continuous IV infusion and the labetalol group; received 0.25 mg/kg loading dose of IV labetalol followed by 0.5–1 mg/kg/h continuous IV infusion to achieve a mean arterial blood pressure (MABP) of = 55–65 mmHg. The primary outcome was to compare the effect of perioperative magnesium sulfate and labetalol infusion on peripheral perfusion during nasal surgery. The secondary outcomes were the assessment of serum lactate, postoperative pain, time to the first call for pethidine (rescue analgesic) and total pethidine consumption. PPI was comparable between the groups at baseline, intubation, and 5 min. In contrast, magnesium sulfate group had a significantly higher PPI than the labetalol group. The magnesium sulfate group had a significantly higher MABP and heart rate compared to labetalol group. The time to reach the target MABP was significantly prolonged in magnesium sulfate than the labetalol group [21.6 ± 1.7 vs 6.9 ± 1.5] min. VAS scores were significantly lower for 2 hs postoperatively in the magnesium sulfate group than the labetalol group. The time to first call of pethidine was significantly prolonged in the magnesium sulfate group compared to the labetalol group [113.1 ± 5.2 vs 28.2 ± 1.5] min. Magnesium sulfate maintains wider PPI and offers better postoperative pain relief compared to labetalol during induced hypotension in nasal surgery. Institutional review board approval (ref: 6601/20–12-2020). Clinicaltrial.gov (ref: NCT04688203 , date of registration: 29 -12–2020).
Craniotomy 2021 /prospect 1 CRANIOTOMY SUMMARY
Phaeochromocytoma—recent progress in its management - British
Abstracts - 2023 - Anaesthesia - Wiley Online Library
Efficacy of intraoperative magnesium sulfate versus ketamine on
Frontiers The effects of perioperative dexmedetomidine infusion
Anaesthesia for laparoscopic surgeries
Effects of perioperative magnesium sulfate infusion on
80th Abstract Supplement Cover.qxp - IARS
Anaesthesia for laparoscopic surgeries
Retrospective analysis of the association between intraoperative
Recomendado para você
-
Rx Item-Labetalol 5Mg/Ml Vial 40Ml By Hospira Worldwide29 maio 2024
-
Labetalol: Side Effects, Dosage, Uses, and More29 maio 2024
-
LABESOL Labetalol HCl Injection USP » SGPharma29 maio 2024
-
Betalor 5/25mg com 30 cápsulas - Ache29 maio 2024
-
Labetalol HCL Injection, USP, 100mg, 20mL Vial29 maio 2024
-
Fosun Pharma USA Inc 72266010301 - McKesson Medical-Surgical29 maio 2024
-
Hospira 00409226754 - McKesson Medical-Surgical29 maio 2024
-
Figure 5 from The low/high BCS permeability class boundary: physicochemical comparison of metoprolol and labetalol.29 maio 2024
-
Labetalol HCL Market: Comprehensive Assessment by Type, Application, and Geography, by Nolalockman, Dec, 202329 maio 2024
-
Adam Horne - Actor - Carolina Talent29 maio 2024
você pode gostar
-
ARMADILHAS QUE ESTOU APRENDENDO NAS NOVAS ABERTURAS29 maio 2024
-
Nintendo detalha futuro DLC para New Super Mario Bros. 229 maio 2024
-
2 Pcs jogos por telefone Alças jogo telefone celular com29 maio 2024
-
Painel Toca Life World G - Frete Grátis29 maio 2024
-
Stream RC Strasbourg Alsace Listen to podcast episodes online for free on SoundCloud29 maio 2024
-
1ª Temporada - Fairy Tail (Dublado)29 maio 2024
-
The Ending of Sakurasou no Pet na Kanojo Sucked [Light Novel Spoilers] –29 maio 2024
-
Future Events - Two Piece and MC powers REVEALED29 maio 2024
-
Ling'er, Martial Peak (MP) Wiki29 maio 2024
-
Rokudenashi Majutsu Koushi to Akashic Records – 02 – RABUJOI – An Anime Blog29 maio 2024