Survival in patients with Parkinson's disease: a ten-year follow
Por um escritor misterioso
Last updated 16 junho 2024
Background A thorough understanding of the factors that influence patient survival in Parkinson’s disease (PD) will aid in prognosis prediction and provide a new direction for disease modification treatment. Currently, there are no standardized mortality ratio (SMR) data for PD patients in the northern Chinese mainland. The main focus of this study was to determine which factors in the prospectively collected baseline characteristics can affect the survival of PD patients. In addition, for the first time, we investigated the SMR of PD patients in northern China. Methods Between 2009 and 2012, 218 PD patients were continuously recruited from the movement disorder clinic of the First Affiliated Hospital of Dalian Medical University and followed up until death or May 31, 2021. The prespecified prognostic variables were demographics, clinical features, lifestyle factors, and drug dose prospectively collected at baseline. To determine the independent predictors of survival during follow-up, the Cox proportional hazards model was used. Kaplan–Meier analysis was applied to estimate the overall survival curve and to compare survival between layers based on statistically significant predictors. The SMR of this northern Chinese mainland PD cohort was calculated. Results After a mean follow-up of 9.58 ± 2.27 years, 50 patients (22.90%) died. Factors that could individually predict shortened survival during follow-up included older age at onset (hazard ratio [HR] 1.10, 95% confidence interval [CI] 1.06–1.15), Hoehn and Yahr (H&Y) stage ≥ 3 (HR 9.36, 95% CI 2.82–31.03) and severe cognitive impairment (HR 6.18, 95% CI 2.75–13.88). Univariate Cox regression revealed that a certain amount of physical activity was associated with better survival (HR 0.41, 95% CI 0.22–0.74), while fatigue was associated with an increased risk of death (HR 2.54, 95% CI 1.37–4.70). The overall SMR was 1.32 (95% CI 0.98–1.74). Conclusions Older age at onset, higher baseline H&Y stage, and severe cognitive impairment have a negative impact on survival. The 10-year survival of PD patients is not significantly different from that of the general population in China.
Prediagnostic presentations of Parkinson's disease in primary care: a case-control study - ScienceDirect
10+ Facts About Parkinson's Disease: Statistics and Realities
Home Page: Parkinsonism & Related Disorders
Survival in patients with Parkinson's disease: a ten-year follow-up study in northern China, BMC Neurology
The Numbers Behind Parkinson's Disease
Five-Year Follow-up of Bilateral Stimulation of the Subthalamic Nucleus in Advanced Parkinson's Disease
Ten year survival and outcomes in a prospective cohort of new onset Chinese Parkinson's disease patients
Impact of Off-Time on Quality of Life in Parkinson's Patients and Their Caregivers: Insights from Social Media
QuickStats: Age-Adjusted Death Rates for Parkinson Disease Among Adults Aged ≥65 Years — National Vital Statistics System, United States, 1999–2017
Long-term outcomes following deep brain stimulation for Parkinson's disease in: Journal of Neurosurgery Volume 132 Issue 1 (2019) Journals
Pesticides Not Only Linked to Parkinson's Disease Development, But Accelerating Disease Symptoms - Beyond Pesticides Daily News Blog
Age at symptom onset and long-term survival in patients with neurofibromatosis Type 2 in: Journal of Neurosurgery Volume 99 Issue 3 (2003) Journals
Recomendado para você
-
Servicos Bronstein16 junho 2024
-
In Memoriam: Remembering Gustav Meier – Peabody Magazine16 junho 2024
-
Unidade Madureira > Laboratórios16 junho 2024
-
LUCRO LÍQUIDO DA NEOENERGIA SOFRE QUEDA DE 92,2% NO SEGUNDO16 junho 2024
-
Bronstein - Nos últimos 10 anos o número de brasileiros com16 junho 2024
-
Bronstein16 junho 2024
-
Emília festas & eventos16 junho 2024
-
Kaplan-Meier analysis of clinical outcomes in critical COVID-1916 junho 2024
-
These testimonies speak for themselves. #cyberbullyingkills #donotuseyourdeviceasaweapon Nate Bronstein, forever 1516 junho 2024
-
TOBIAS MEIER Balanced complexity with fine art - Photography16 junho 2024
você pode gostar
-
Jogue Rip City, Jogo do Gato16 junho 2024
-
A Plague Tale 3 – Vše, co víme (SPEKULACE)16 junho 2024
-
GUN MASTER 2 - Play Online for Free!16 junho 2024
-
Trainer Requests16 junho 2024
-
Baby Reborn parents: the routine of people who formed a family with realistic dolls16 junho 2024
-
Call of Duty: Advanced Warfare Nexus - Mods and community16 junho 2024
-
Premium AI Image Closeup Wallpaper chess pieces on a board16 junho 2024
-
More R-Rated Disney+ Movies & Shows Are on the Way16 junho 2024
-
La nueva Auxiliar del Club Ferrocarril Oeste de Buenos Aires está en su recta final – Info Deportes16 junho 2024
-
Jurassic World Dominion review – prehistory repeats itself16 junho 2024