Genes that Escape Silencing on the Second X Chromosome May Drive Disease

When X-linked genes evade silencing on the “inactive” chromosome in XX cells, some protect women from diseases such as cancer, but others seem to promote conditions such as autoimmunity.

Frontiers X Inactivation and Escape: Epigenetic and Structural Features

Frontiers Chromosome X-wide Analysis of Positive Selection in Human Populations: Common and Private Signals of Selection and its Impact on Inactivated Genes and Enhancers

Genes that escape from X‐chromosome inactivation: Potential contributors to Klinefelter syndrome - Navarro‐Cobos - 2020 - American Journal of Medical Genetics Part C: Seminars in Medical Genetics - Wiley Online Library

When the balance is broken: X‐linked gene dosage from two X chromosomes and female‐biased autoimmunity - Syrett - 2019 - Journal of Leukocyte Biology - Wiley Online Library

Genes that Escape Silencing on the Second X Chromosome May Drive Disease

Frontiers X-Chromosome Inactivation and Autosomal Random Monoallelic Expression as “Faux Amis”

Integrated analysis of Xist upregulation and X-chromosome inactivation with single-cell and single-allele resolution

The human inactive X chromosome modulates expression of the active X chromosome - ScienceDirect

Chromosome compartments on the inactive X guide TAD formation independently of transcription during X-reactivation

X chromosome regions. Regions in the X chromosome are: Xp (short arm)

Genetic and epigenetic features direct differential efficiency of Xist-mediated silencing at X-chromosomal and autosomal locations