Replicatively senescent cells are arrested in G1 and G2 phases - Figure F1

Senescent human fibroblast cultures contain a large fraction of putative G2-arrested cells with 4N DNA content. (A) Propidium iodide (PI) staining and flow cyctometric analysis of HCA2 normal human foreskin fibroblasts. Cells entered senescence at PD73. (B) PI staining of replicatively senescent human lung fibroblasts WI-38, and IMR-90 at PDs 73 and 68 respectively. (C) The fraction of 4N cells in senescent cell population does not diminish with time. Replicatively senescent HCA2 cells were analyzed by PI staining at weekly intervals for 10 weeks stating from the onset of senescence.

Quantitative profiling of adaptation to cyclin E overproduction

Overview of origin licensing during the cell division cycle.A

Necessary and Sufficient Role for a Mitosis Skip in Senescence

The lack of functional DNMT2/TRDMT1 gene modulates cancer cell

Fueling the Cell Division Cycle: Trends in Cell Biology

Releasing YAP dysfunction‐caused replicative toxicity rejuvenates

Replicatively senescent cells are arrested in G1 and G2 phases

Full article: Senescence from G2 arrest, revisited

Necessary and Sufficient Role for a Mitosis Skip in Senescence