Local Protein Synthesis and Spine Morphogenesis: Fragile X Syndrome and Beyond

Behavioral experiences can modulate neural networks through changes in synaptic morphology and number. In contrast, abnormal morphogenesis of dendritic spines is associated with cognitive impairment, as in Fragile X syndrome. Dendritic or synaptic protein synthesis could provide the specificity and speed necessary for spine morphogenesis. Here, we highlight locally translated proteins shown to affect synaptic morphology (e.g., Fragile X mental retardation protein).

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Fragile X Syndrome: Loss of Local mRNA Regulation Alters Synaptic

Fragile X Syndrome: Loss of Local mRNA Regulation Alters Synaptic

Fragile X mental retardation protein in intrahepatic

Dissociation of functional and structural plasticity of dendritic spines

Frontiers Local mRNA translation and cytoskeletal reorganization

PDF) Fragile X syndrome: Are signaling lipids the missing culprits?

Fragile X mental retardation protein controls synaptic vesicle

Frontiers Fragile X mental retardation protein is involved in

Pten heterozygosity restores neuronal morphology in fragile X

Roles of CREB in the regulation of FMRP by group I metabotropic