JCM, Free Full-Text
Por um escritor misterioso
Last updated 15 junho 2024
Overt hyperthyroidism (HT) during pregnancy is associated with a risk of maternal–fetal complications. Antithyroid drugs (ATD) have a potential risk for teratogenic effects and fetal–neonatal hypothyroidism. This study evaluated ATD treatment and thyroid function control during pregnancy, and pregnancy outcome in women with HT. Patients and methods: A retrospective analysis of 36 single fetus pregnancies in 29 consecutive women (median age 30.3 ± 4.7 years) with HT diagnosed before or during pregnancy; a control group of 39 healthy euthyroid pregnant women was used. Results: Twenty-six women had Graves’ disease (GD, 33 pregnancies), 1 had a hyperfunctioning autonomous nodule, and 2 had gestational transient thyrotoxicosis (GTT). Methimazole (MMI) was administered in 22 pregnancies (78.5%), Propylthiouracil (PTU) in 2 (7.1%), switch from MMI to PTU in 4 (14.2%), no treatment in 8 pregnancies (3 with subclinical HT, 5 euthyroid with previous GD remission before conception). In the 8 pregnancies of GD patients diagnosed during gestation or shortly before (<6 weeks), i.e., with fetal exposure to uncontrolled HT, there was 1 spontaneous abortion at 5 weeks (3.4% of all ATD-treated pregnancies), and 1 premature delivery at 32 weeks with neonatal death in 24 h (3.4%); 1 child had neonatal hyperthyroidism (3.3% of live children in GD women) and a small atrial sept defect (4% of live children in ATD treated women). In women treated more than 6 months until conception (20 pregnancies): (a) median ATD doses were lower than those in women diagnosed shortly before or during pregnancy; (b) ATD was withdrawn in 40% of pregnancies in trimester (T)1, all on MMI < 10 mg/day (relapse in 14.2%), and in up to 55% in T3; (c) TSH level was below normal in 37%, 35% and 22% of pregnancies in T1, T2 and T3 respectively; FT4 was increased in 5.8% (T1) and subnormal in 11.75% in T2 and T3; (d) no fetal birth defects were recorded; one fetal death due to a true umbilical cord knot was registered. Mean birth weight was similar in both ATD-treated and control groups. Hyperthyroidism relapsed postpartum in 83% of GD patients (at median 3 ± 2.6 months). Conclusion: In hyperthyroid women with long-term ATD treatment before conception, drugs could be withdrawn in T1 in 40% of them, the thyroid function control was better, and pregnancy and fetal complications were rarer, compared to women diagnosed during pregnancy. Frequent serum TSH and FT4 monitoring is needed to maintain optimal thyroid function during pregnancy.
JCM, Free Full-Text
Author Instructions - AIP Publishing LLC
Marshall JCM2000 Triple Super Lead 100 Head
Connectional Young Adult Ministry
Home
JCM, Free Full-Text
Marshall JCM 800 MK2 Master Model 100w Lead 1986
Kajabi: Create and sell online courses, coaching, and memberships
JCM, Free Full-Text
Pizza Delivery & Carryout, Pasta, Chicken & More
JCM, Free Full-Text
Recomendado para você
-
9/11 2022 Remembrance Ceremony > Vandenberg Space Force Base > Article Display15 junho 2024
-
Solved Eu Eu - Euuuu Hb concentration 14 13.5 15.1 16.4 12.415 junho 2024
-
List of runner numbers15 junho 2024
-
Winter Slippers Plush Warm Home Flat Slippers Lightweight Soft Comfortable Winter SlippersCotton Shoes Indoor Plush Slippers Winter Slippers (Color : F, Shoe Size : 36-37) : Clothing, Shoes & Jewelry15 junho 2024
-
EXCELLO GLOBAL PRODUCTS Excello 37 in. x 36 in. Swinging Message Board Sign, Black EGP-HD-0193-OS - The Home Depot15 junho 2024
-
Basel, Universitätsbibliothek, AN II 36, f. 37v – Biblia germanica, 1st part - PICRYL - Public Domain Media Search Engine Public Domain Search15 junho 2024
-
ADAP37(F/M) MINI direct connect terminal adapter cards - ACCES I/O Products15 junho 2024
-
50th IEEE PVSC on X: Revised list - cheers to all our runners at the 41st IEEE PVSC Sun Run! #solar #renewableenergy #PVSC48 / X15 junho 2024
-
A Carbon-Phosphorus Bond in Nature15 junho 2024
-
2007 TELLU-TRI TRIATHLON Final Ranking by - Colorado Runner15 junho 2024
você pode gostar
-
Manga Volume 3, The Rising of the Shield Hero Wiki15 junho 2024
-
Code Geass Lelouch Vi Britannia Lamperouge Emperor King Cosplay Costume Full Set15 junho 2024
-
NARUTO SHIPPUDEN 5 TEMPORADA, Wiki15 junho 2024
-
Teste de Velocidade: Internet Vivo Fibra RJ 300 Megas - Vale a Pena?15 junho 2024
-
BOA CHINA !!! UNBOXING CHAPÉU DO ACEE XD15 junho 2024
-
NEW Funky Friday REAL Auto Player Script Hydrogen and Fluxus - Roblox Mobile Exploiting15 junho 2024
-
What You Can Learn From An Old Gym Rat15 junho 2024
-
Nerf Fortnite Heavy SR Blaster15 junho 2024
-
How Garry Kasparov aims to boost chess revival with online gaming15 junho 2024
-
Boneca Princesas Disney Frozen Anna Disney Multikids - BR192215 junho 2024