Cancers, Free Full-Text

Overexpression of Exportin-1 (XPO1), a key regulator of nuclear-to-cytoplasmic transport, is associated with inferior patient outcomes across a range of adult malignancies. Targeting XPO1 with selinexor has demonstrated promising results in clinical trials, leading to FDA approval of its use for multiple relapsed/refractory cancers. However, XPO1 biology and selinexor sensitivity in childhood cancer is only recently being explored. In this review, we will focus on the differential biology of childhood and adult cancers as it relates to XPO1 and key cargo proteins. We will further explore the current state of pre-clinical and clinical development of XPO1 inhibitors in childhood cancers. Finally, we will outline potentially promising future therapeutic strategies for, as well as potential challenges to, integrating XPO1 inhibition to improve outcomes for children with cancer.

Multi-omics integrated circulating cell-free DNA genomic

Cancers, Free Full-Text

PDF) Discovery and validation of methylation signatures in

Celltracker Zip Get File - Colaboratory

Multimodal analysis of methylomics and fragmentomics in plasma

The Decrease in Breast-Cancer Incidence in 2003 in the United

Cancer burden among adolescents and young adults in relation to

Cancers An Open Access Journal from MDPI

Adagrasib in Non–Small-Cell Lung Cancer Harboring a KRASG12C

Game Rong Den 5 Get File - Colaboratory

Cancers, Free Full-Text

Classification of biliary tract cancers established by JSHBPS: 3rd

Mortality after second malignancy in breast cancer survivors

Cancer Innovation - Wiley Online Library

Cancer - Wiley Online Library