Brain Sciences, Free Full-Text
Por um escritor misterioso
Last updated 24 junho 2024
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Neuroinflammation is often accompanied by central nervous system (CNS) injury seen in various CNS diseases, with no specific treatment. Drug repurposing is a strategy of finding new uses for approved or investigational drugs, and can be enabled by the Library of Integrated Network-based Cellular Signatures (LINCS), a large drug perturbation database. In this study, the signatures of Lipopolysaccharide (LPS) were compared with the signatures of compounds contained in the LINCS dataset. To the top 100 compounds obtained, the Quantitative Structure-Activity Relationship (QSAR)-based tool admetSAR was used to identify the top 10 candidate compounds with relatively high blood–brain barrier (BBB) penetration. Furthermore, the seventh-ranked compound, dutasteride, a 5-α-reductase inhibitor, was selected for in vitro and in vivo validation of its anti-neuroinflammation activity. The results showed that dutasteride significantly reduced the levels of IL-6 and TNF-α in the supernatants of LPS-stimulated BV2 cells, and decreased the levels of IL-6 in the hippocampus and plasma, and the number of activated microglia in the brain of LPS administration mice. Furthermore, dutasteride also attenuated the cognitive impairment caused by LPS stimulation in mice. Taken together, this study demonstrates that the LINCS dataset-based drug repurposing strategy is an effective approach, and the predicted candidate, dutasteride, has the potential to ameliorate LPS-induced neuroinflammation and cognitive impairment.
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Stream {PDF} ❤ Reading in the Brain: The New Science of How We
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Human brain science themed design graphic Vector Image
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Brain Surrogates—Empty or Full Makes the Difference: The American
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Evidence of a predictive coding hierarchy in the human brain
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Brain Sciences An Open Access Journal from MDPI
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Brain Sciences An Open Access Journal from MDPI
General and specific brain regions involved in encoding and
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Split-brain - Wikipedia
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Mini Dsm-Iv-Tr Get File - Colaboratory
Reading in the brain : the new science of how we read : Dehaene
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Brain Computer Interface Seminar Ppt Free Download - Colaboratory
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Community Learning Collective: My Brain, My Body, What is
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Science News email newsletters
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Brain Sciences, Free Full-Text
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